Holders Barcelona fell to a shock 2-1 defeat to Levante in the first leg of their Copa Del Rey last-16 tie.
Erick Cabaco and Borja Mayoral scored in the opening 20 minutes to give the hosts a comfortable lead at half-time.
Brazilian midfielder Philippe Coutinho pulled a goal back for Barcelona with a late penalty.
The defeat came just three weeks after Barca had thrashed Levante 5-0 in the league, with Lionel Messi scoring a hat-trick.
Messi was one of several omissions from Ernesto Valverde’s much-changed side.
The second leg will take place at the Nou Camp on Thursday.